{"id":8941,"date":"2023-12-18T13:51:48","date_gmt":"2023-12-18T13:51:48","guid":{"rendered":"https:\/\/doctorathens.com\/the-autonomization-principle-in-vascularized-flaps-an-alternative-strategy-for-composite-tissue-scaffold-in-vivo-revascularization\/"},"modified":"2023-12-18T13:51:48","modified_gmt":"2023-12-18T13:51:48","slug":"the-autonomization-principle-in-vascularized-flaps-an-alternative-strategy-for-composite-tissue-scaffold-in-vivo-revascularization","status":"publish","type":"post","link":"https:\/\/doctorathens.com\/en\/the-autonomization-principle-in-vascularized-flaps-an-alternative-strategy-for-composite-tissue-scaffold-in-vivo-revascularization\/","title":{"rendered":"The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8941\" class=\"elementor elementor-8941 elementor-6610\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8bde92d e-con-full e-flex wcf-starter-animations-none e-con e-parent\" data-id=\"8bde92d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f382550 elementor-widget__width-initial wcf-starter-animations-none elementor-widget elementor-widget-wcf--blog--post--title\" data-id=\"f382550\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;wcf_starter_animations&quot;:&quot;none&quot;,&quot;wcf_anim_duration&quot;:1000,&quot;wcf_anim_delay&quot;:0,&quot;wcf_anim_ease&quot;:&quot;ease&quot;,&quot;delay&quot;:0.1499999999999999944488848768742172978818416595458984375,&quot;on-scroll&quot;:1,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;data-duration&quot;:1.5,&quot;ease&quot;:&quot;power2.out&quot;,&quot;fade-offset&quot;:50}\" data-widget_type=\"wcf--blog--post--title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"wcf--title\">The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-097542e elementor-widget elementor-widget-wcf--blog--post--meta-info\" data-id=\"097542e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;delay&quot;:0.1499999999999999944488848768742172978818416595458984375,&quot;on-scroll&quot;:1,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;data-duration&quot;:1.5,&quot;ease&quot;:&quot;power2.out&quot;,&quot;fade-offset&quot;:50}\" data-widget_type=\"wcf--blog--post--meta-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <ul class=\"wcf--meta-list style-1\">\r\n\t\t\t\t\t\t                <li class=\"wcf--meta-date wcf-separator\"\r\n                    data-separator=\"\">\r\n                    \t\t\t\t\t\t\t\t\t\t18\/12\/2023                <\/li>\r\n\t\t\t\r\n\t\t\t\t\t        <\/ul>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6690893 e-con-full e-flex wcf-starter-animations-none e-con e-child\" data-id=\"6690893\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div data-speed=\"0.9\" class=\"elementor-element elementor-element-9c7d7be wcf-starter-animations-none elementor-widget elementor-widget-wcf--image\" data-id=\"9c7d7be\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf_starter_animations&quot;:&quot;none&quot;,&quot;wcf_anim_duration&quot;:1000,&quot;wcf_anim_delay&quot;:0,&quot;wcf_anim_ease&quot;:&quot;ease&quot;,&quot;wcf-image-animation&quot;:&quot;none&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"wcf--image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"wcf--image\">\r\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"700\" src=\"https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post.webp\" class=\"attachment-full size-full wp-image-7166\" alt=\"vascularized-flaps-post\" srcset=\"https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post.webp 1920w, https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post-300x109.webp 300w, https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post-1024x373.webp 1024w, https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post-768x280.webp 768w, https:\/\/doctorathens.com\/wp-content\/uploads\/2025\/11\/vascularized-flaps-post-1536x560.webp 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-59e3197 e-flex e-con-boxed wcf-starter-animations-none e-con e-parent\" data-id=\"59e3197\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f1b9241 e-con-full e-flex wcf-starter-animations-none e-con e-child\" data-id=\"f1b9241\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;wcf_enable_cursor_hover_effect_text&quot;:&quot;View&quot;,&quot;wcf-animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8aa230b wcf-starter-animations-none wcf-t-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"8aa230b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;on-scroll&quot;:&quot;1&quot;,&quot;wcf_starter_animations&quot;:&quot;none&quot;,&quot;wcf_anim_duration&quot;:1000,&quot;wcf_anim_delay&quot;:0,&quot;wcf_anim_ease&quot;:&quot;ease&quot;,&quot;wcf_text_animation&quot;:&quot;none&quot;,&quot;delay&quot;:0.1499999999999999944488848768742172978818416595458984375,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;data-duration&quot;:1.5,&quot;ease&quot;:&quot;power2.out&quot;,&quot;fade-offset&quot;:50}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract<\/strong><\/p><p>\u00a0<\/p><p>Autonomization is a physiological process allowing a flap to develop neo-vascularization\u00a0from the reconstructed wound bed. This phenomenon has been used since the early application of flap surgeries but still remains poorly understood. Reconstructive strategies have greatly evolved since, and fasciocutaneous flaps have progressively replaced muscle-based reconstructions, ensuring better functional outcomes with great reliability. However, plastic surgeons still encounter challenges in complex cases where conventional flap reconstruction reaches its limitations. Furthermore, emerging bioengineering applications, such as decellularized scaffolds allowing a complex extracellular matrix to be repopulated with autologous cells, also face the complexity of revascularization. The objective of this article is to gather evidence of autonomization phenomena. A systematic review of flap autonomization is then performed to document the minimum delay allowing this process. Finally, past and potential applications in bio- and tissue-engineering approaches are discussed, highlighting the potential for in vivo revascularization of acellular scaffolds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-485cfba elementor-align-center elementor-widget elementor-widget-button\" data-id=\"485cfba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38136031\/\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read Full Article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff4526a elementor-widget elementor-widget-wcf--blog--post--tags\" data-id=\"ff4526a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;wcf-animation&quot;:&quot;fade&quot;,&quot;delay&quot;:0.1499999999999999944488848768742172978818416595458984375,&quot;on-scroll&quot;:1,&quot;fade-from&quot;:&quot;bottom&quot;,&quot;data-duration&quot;:1.5,&quot;ease&quot;:&quot;power2.out&quot;,&quot;fade-offset&quot;:50}\" data-widget_type=\"wcf--blog--post--tags.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div class=\"wcf--post-tags\">\r\n\t\t\t        <\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization December 18, 2023 Abstract \u00a0 Autonomization is a physiological process allowing a flap to develop neo-vascularization\u00a0from the reconstructed wound bed. This phenomenon has been used since the early application of flap surgeries but still remains poorly understood. Reconstructive strategies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8520,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-8941","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/posts\/8941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/comments?post=8941"}],"version-history":[{"count":0,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/posts\/8941\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/media\/8520"}],"wp:attachment":[{"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/media?parent=8941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/categories?post=8941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/doctorathens.com\/en\/wp-json\/wp\/v2\/tags?post=8941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}